Friday, September 26, 2025

IRS Economic Substance Argument Does Not Trump 482 Rules as Perrigo Wins $163M Refund


In a significant victory for multinational businesses, the U.S. District Court for the Western District of Michigan recently sided with pharmaceutical giant Perrigo Company in its long-running $163 million tax refund dispute with the IRS. The battle centered on the complex interplay of the economic substance doctrine and Section 482 transfer pricing regulations, providing an important precedent for cross-border tax planning.

Background: Transfers and IRS Scrutiny

Perrigo’s case involved income earned by its Israeli affiliate from sales of omeprazole between 2009 and 2012. The IRS challenged Perrigo’s transfer pricing arrangements, alleging the use of a foreign subsidiary amounted to an artificial structure designed primarily for tax avoidance. Instead of relying solely on Section 482, the well-established transfer pricing framework, the IRS pressed its case by invoking the codified economic substance doctrine, arguing that the subsidiary and related-party transactions lacked legitimate business purpose.

The Court’s Decision: Section 482 Prevails

The Michigan federal court rejected the government’s position, affirming that Perrigo’s arrangements fell squarely within the regulatory boundaries set by Section 482. 

The Court Declined To Give Precedence
To The IRS’s Economic Substance Arguments, Noting That The Detailed Transfer Pricing Rules Already
Encompass The Necessary Tests For Legitimacy, Including Whether Transactions Have Real Economic Substance.

Ultimately, the court found in favor of Perrigo, recognizing the validity of its cross-border arrangements and rendering the company entitled to much of its $163 million tax refund. The decision limits the reach of the economic substance doctrine in cases where Congress has crafted a detailed regulatory framework.

Lessons for Multinationals and Practitioners

This case highlights a crucial crossroads in international tax law. While the IRS has signaled a more aggressive strategy using the economic substance doctrine to challenge cross-border transactions, this court ruling underscores the primacy of specific transfer pricing regulations when they fully address the relevant issues. The outcome is a welcome development for businesses relying on robust documentation and arm’s-length principles in their international structures.

The ruling also sends a clear message: courts may resist broad anti-avoidance doctrines when a statutory or regulatory scheme like Section 482 already provides detailed rules and oversight. Nevertheless, taxpayers should anticipate continued IRS scrutiny of related-party transactions and be prepared to defend both the economic substance and the arm’s-length nature of their structures.

Conclusion

The Perrigo case is a bellwether for future disputes at the nexus of transfer pricing and economic substance. Multinationals can take some comfort that careful compliance with Section 482 remains a strong defense, but vigilance is still required as the IRS refines its strategies and aggressively asserts penalties in international tax cases. The evolving landscape calls for sophisticated planning and, above all, meticulous substantiation of global tax positions.

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